![]() Therefore, patients with a negative test result should be retested periodically Patients who are anti-JCV antibody negative are still at risk for the development of PML due to the potential for a new JCV infection or a false negative test result.There may be other risk factors that have not yet been identified ![]() Your risk of getting PML is greatest if you have all 3 risk factors listed above.have received certain medicines that can weaken your immune system before you start receiving TYSABRI.have received TYSABRI for a long time, especially for longer than 2 years.Before or while you receive TYSABRI, your doctor may do a blood test to check if you have been infected by JCV JCV is a common virus that can cause PML in people who have weakened immune systems, such as people taking TYSABRI. have been infected by the John Cunningham Virus (JCV).Your risk of getting PML is higher if you:.Even if you use TYSABRI alone to treat your MS, you can still get PML You should not take certain medicines that weaken your immune system at the same time you are taking TYSABRI.There is no known treatment, prevention, or cure for PML.TYSABRI increases your risk of getting a rare brain infection-called progressive multifocal leukoencephalopathy (PML)-that usually leads to death or severe disability. What is the most important information I should know about TYSABRI?
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